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KMID : 0603520020070020108
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Journal of Korean Association of Cancer Prevention
2002 Volume.7 No. 2 p.108 ~ p.115
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Anti-tumor Promoting Potential of Artemisia asiatica
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Seo Hyo-Joung
Chun Kyung-Soo
Surh Young-Joon
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Abstract
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Artemisia asiatica Nakai (Asteraceae) has been used in traditional oriental medicine for the treatment of inflammation and other disorders. As an initial approach towards determining the possible anti-tumor promoting potential of A. asiatica, the effects of the ethanol extract of this plant on I2-O-tetradecanoylphorbol-l3-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were examined in female ICR mice. Pretreatment of the shaven back of mice with A. asiatica 30 min prior to topical application of TPA inhibited expression of these enzymes in a dose-dependent manner. Morover, A. asiatica treatment attenuated TPA-stimulated epidermal NF-kB activation, which was associated with its blockade of degradation of the inhibitory protein I kB a and also of subsequent translocation of the p65 subunit to nucleus. Our findings that A. asiatica inhibits TPA-induced COX-2 and iNOS expression by blocking the NF-kB signaling cascades may provide molecular basis for suppression of mouse skin inflammation and tumor promotion by this chemopreventive plant.
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KEYWORD
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Anti-tumor promotion, Cyclooxygenas-2, Inducible nitric oxide synthase Mouse skin, NF-KB
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